Synthesis, Molecular Docking, and Antitumor Evaluation of Some New Pyrazole, Pyridine, and Thiazole Derivatives Incorporating Sulfonamide Residue

Cancer is the second leading cause of death worldwide. There always a huge demand for novel anticancer. New series pyrazole, pyridine, thiazole derivatives containing sulfonamide moiety were prepared and screened their antitumor activity against breast cancer cell line (MCF-7). The results this investigation revealed that compounds 3 8 had significant anticancer MCF-7 with IC50 values 19.2 14.2 µM, respectively, in relation to standard drug, doxorubicin.